User profiles for A. L. Routh
Andrew RouthScripps Research, La Jolla Verified email at scripps.edu Cited by 4724 |
[HTML][HTML] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
[HTML][HTML] The coronavirus proofreading exoribonuclease mediates extensive viral recombination
…, JD Chappell, X Lu, AJ Pruijssers, AL Routh… - PLoS …, 2021 - journals.plos.org
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …
[HTML][HTML] Furin cleavage site is key to SARS-CoV-2 pathogenesis
SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world.
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
[HTML][HTML] Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation
outside of the spike gene remains largely unexplored. This study investigates a highly …
outside of the spike gene remains largely unexplored. This study investigates a highly …
[HTML][HTML] Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
resulted in a pandemic causing significant damage to public health and the economy. Efforts …
resulted in a pandemic causing significant damage to public health and the economy. Efforts …
[PDF][PDF] Dengue NS2A protein orchestrates virus assembly
Dengue virus assembly requires cleavage of viral C-prM-E polyprotein into three structural
proteins (capsid, premembrane, and envelope), packaging of viral RNA with C protein into …
proteins (capsid, premembrane, and envelope), packaging of viral RNA with C protein into …
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis
…, DH Walker, WK Russell, AL Routh… - Proceedings of the …, 2022 - National Acad Sciences
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike …
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike …
Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity
How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear.
Previously we found that, Serratia, a gut symbiont that alters vector competence and is …
Previously we found that, Serratia, a gut symbiont that alters vector competence and is …
Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and
to identify adaptations that affect pathogenicity or transmission. While single-nucleotide …
to identify adaptations that affect pathogenicity or transmission. While single-nucleotide …
[HTML][HTML] Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection
SARS-CoV-2 Omicron variants emerged in 2022 with> 30 novel amino acid mutations in the
spike protein alone. While most studies focus on receptor binding domain changes, …
spike protein alone. While most studies focus on receptor binding domain changes, …