User profiles for A. L. Routh

Andrew Routh

Scripps Research, La Jolla
Verified email at scripps.edu
Cited by 4724

[HTML][HTML] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

…, V Popov, B Lee, SC Weaver, MS Suthar, AL Routh… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …

[HTML][HTML] The coronavirus proofreading exoribonuclease mediates extensive viral recombination

…, JD Chappell, X Lu, AJ Pruijssers, AL Routh… - PLoS …, 2021 - journals.plos.org
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …

[HTML][HTML] Furin cleavage site is key to SARS-CoV-2 pathogenesis

…, KS Plante, B Lee, SC Weaver, MS Suthar, AL Routh… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world.
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …

[HTML][HTML] Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

…, SC Weaver, PY Shi, DH Walker, AL Routh… - PLoS …, 2022 - journals.plos.org
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation
outside of the spike gene remains largely unexplored. This study investigates a highly …

[HTML][HTML] Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

…, KS Plante, SC Weaver, K Debbink, AL Routh… - PLoS …, 2021 - journals.plos.org
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
resulted in a pandemic causing significant damage to public health and the economy. Efforts …

[PDF][PDF] Dengue NS2A protein orchestrates virus assembly

X Xie, J Zou, X Zhang, Y Zhou, AL Routh, C Kang… - Cell host & …, 2019 - cell.com
Dengue virus assembly requires cleavage of viral C-prM-E polyprotein into three structural
proteins (capsid, premembrane, and envelope), packaging of viral RNA with C protein into …

QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis

…, DH Walker, WK Russell, AL Routh… - Proceedings of the …, 2022 - National Acad Sciences
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike …

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity

…, Y Zhou, Y Fovanov, SC Weaver, AL Routh… - The ISME …, 2021 - academic.oup.com
How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear.
Previously we found that, Serratia, a gut symbiont that alters vector competence and is …

Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

…, TG Ksiazek, VD Menachery, SC Weaver, AL Routh - Elife, 2021 - elifesciences.org
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and
to identify adaptations that affect pathogenicity or transmission. While single-nucleotide …

[HTML][HTML] Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection

…, SC Weaver, DH Walker, WK Russell, AL Routh… - BioRxiv, 2023 - ncbi.nlm.nih.gov
SARS-CoV-2 Omicron variants emerged in 2022 with> 30 novel amino acid mutations in the
spike protein alone. While most studies focus on receptor binding domain changes, …