10.7554/eLife.03401.001 Gene drives may be capable of addressing ecological problems by
altering entire populations of wild organisms, but their use has remained largely theoretical …

If they are able to spread in wild populations, CRISPR-based gene-drive elements would
provide new ways to address ecological problems by altering the traits of wild organisms, but …

… Andrea L Smidler , Andrea L Smidler … transgenes used to obtain mutant mosquitoes in the
immunity gene TEP1 (Smidler et al. 2013). All vectors except the most recent NLS derivatives …

Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body
heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is …

Anopheles gambiae , the main mosquito vector of human malaria, is a challenging organism
to manipulate genetically. As a consequence, reverse genetics studies in this disease …

Transmission of malaria parasites occurs when a female Anopheles mosquito feeds on an
infected host to acquire nutrients for egg development. How parasites are affected by …

Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria
elimination efforts, necessitating development of alternative vector control technologies. Sterile …

The development of an extensive toolkit for potential point-of-care diagnostics that is expeditiously
adaptable to new emerging pathogens is of critical public health importance. Recently…

Malaria is among the world’s deadliest diseases, predominantly affecting Sub-Saharan
Africa and killing over half a million people annually. Controlling the principal vector, the …

When scientists alter the genome of an organism, we typically reduce its ability to reproduce
in the wild. This limitation has prevented researchers from rendering wild insects unable to …