Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development

…, C Houbron, M Dejean, I Reim, AM Cardozo Gizzi… - Nature …, 2021 - nature.com
Acquisition of cell fate is thought to rely on the specific interaction of remote cis-regulatory
modules (CRMs), for example, enhancers and target promoters. However, the precise …

[HTML][HTML] Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

DI Cattoni, AM Cardozo Gizzi, M Georgieva… - Nature …, 2017 - nature.com
At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting
modules or topologically associated domains (TADs) that associate to form nuclear …

[HTML][HTML] A shift in paradigms: Spatial genomics approaches to reveal single-cell principles of genome organization

AM Cardozo Gizzi - Frontiers in Genetics, 2021 - frontiersin.org
… Copyright © 2021 Cardozo Gizzi. This is an open-access article distributed under the terms
of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction …

Direct and simultaneous observation of transcription and chromosome architecture in single cells with Hi-M

AM Cardozo Gizzi, SM Espinola, J Gurgo, C Houbron… - Nature …, 2020 - nature.com
Simultaneous observation of 3D chromatin organization and transcription at the single-cell
level and with high spatial resolution may hold the key to unveiling the mechanisms …

c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides

AR Alfonso Pecchio, AM Cardozo Gizzi… - Molecular biology of …, 2011 - Am Soc Cell Biol
The oncoprotein c-Fos is a well-recognized AP-1 transcription factor. In addition, this protein
associates with the endoplasmic reticulum and activates the synthesis of phospholipids. …

Mechanistic insights into the nongenomic regulation of phospholipid synthesizing enzymes

AM Cardozo Gizzi, BL Caputto - IUBMB life, 2013 - Wiley Online Library
Mechanistic insights into the nongenomic regulation of phospholipid synthesizing enzymes -
Cardozo Gizzi - 2013 - IUBMB Life - Wiley Online Library … Cardozo GizziCardozo Gizzi

Impairing activation of phospholipid synthesis by c-Fos interferes with glioblastoma cell proliferation

…, FN Velazquez, AM Cardozo Gizzi… - Biochemical …, 2020 - portlandpress.com
… The putative ordered domain (amino acids 45–80) proposed by Cardozo-Gizzi et al. [10] is
… The putative ordered domain (amino acids 45–80) proposed by Cardozo-Gizzi et al. [10] is …

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during development

…, JB Fiche, M Bellec, C Houbron, AM Cardozo Gizzi… - Biorxiv, 2020 - biorxiv.org
During development, naïve cells gradually acquire distinct cell fates, through sophisticated
mechanisms of precise spatio-temporal gene regulation. Acquisition of cell fate is thought to …

Single-cell absolute contact probability detection reveals that chromosomes are organized by modulated stochasticity

DI Cattoni, AM Cardozo Gizzi, M Georgieva… - bioRxiv, 2017 - biorxiv.org
The multi-scale organization of eukaryotic genomes defines and regulates cellular identity
and tissue-specific functions 1 – 3 . At the kilo-megabase scales, genomes are partitioned into …

[HTML][HTML] The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development

…, GO Ferrero, FB Plonka, AMC Gizzi… - Journal of Biological …, 2020 - ASBMB
Differentiation of neuronal cells is crucial for the development and function of the nervous
system. This process involves high rates of membrane expansion, during which the synthesis …