Abstract Changes to the conformation of coding and non-coding RNAs form the basis of
elements of genetic regulation and provide an important source of complexity, which drives …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

… Anthony Mustoe is an Assistant Professor of Biochemistry at Baylor College of Medicine. His
… The Mustoe lab is committed to training the next generation of scientists at the experimental-…

mRNAs can fold into complex structures that regulate gene expression. Resolving such
structures de novo has remained challenging and has limited our understanding of the …

7SK is a conserved noncoding RNA that regulates transcription by sequestering the
transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …

Riboswitches are structural elements in the 5′ untranslated regions of many bacterial
messenger RNAs that regulate gene expression in response to changing metabolite …

RNA structure and dynamics are critical to biological function. However, strategies for determining
RNA structure in vivo are limited, with established chemical probing and newer duplex …

RNA–protein interaction networks govern many biological processes but are difficult to
examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational …

Chemical probing experiments have transformed RNA structure analysis, enabling high-throughput
measurement of base-pairing in living cells. Dimethyl sulfate (DMS) is one of the …

Synonymous codon usage has been identified as a determinant of translational efficiency
and mRNA stability in model organisms and human cell lines. However, whether natural …