Alterations in the cytosolic concentration of calcium ions (Ca 2+ ) transmit information that is
crucial for the development and function of B cells. Cytosolic Ca 2+ concentration is …

TRPM2 is a recently identified TRPM family cation channel which is unique among known
ion channels in that it contains a C-terminal domain which is homologous to the NUDT9 ADP-…

Elevation of the cytoplasmic calcium concentration is a common and crucial event which
follows the activation of many types of cell surface receptors. It is produced by the second …

Free ADP-ribose (ADPR), a product of NAD hydrolysis and a breakdown product of the
calcium-release second messenger cyclic ADPR (cADPR), has no defined role as an intracellular …

The molecular mechanisms that regulate basal or background entry of divalent cations into
mammalian cells are poorly understood. Here we describe the cloning and functional …

TRPM7 is a polypeptide with intrinsic ion channel and protein kinase domains whose targeted
deletion causes cells to experience growth arrest within 24 hr and eventually die. Here, …

The TRP superfamily includes a diversity of non-voltagegated cation channels that vary
significantly in their selectivity and mode of activation. Nevertheless, members of the TRP …

… (E) Averaged [Ca 2+ ]i signals in intact wt HEK-293 cells loaded with fura-2-AM and stimulated
by the purinergic receptor agonist ATP (n = 7–10). During the time indicated by the bar, …

… sine-phosphorylated protein in the anti-p58immunopreprotected from phosphatase activity
(Scharenberg et cipitations from these NK cells was a 58 kDa protein comigrating with p58 (…

Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors
(CAR) has emerged as a powerful means of treating cancer. However, a limitation of this …