Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the
effect of different cholesterol-containing diets on the remnant lipoprotein levels and …

Apolipoprotein (apo) E3-Leiden, described in a large Dutch family, is associated with a
dominantly inherited form of familial dysbetalipoproteinemia. To study the effect of the APOE*3-…

Migraine is a common neurological disorder with a genetically complex background. This
paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, …

Background: The blood metabolome incorporates cues from the environment and the host’s
genetic background, potentially offering a holistic view of an individual’s health status. …

By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing
heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed …

… During each session, participants received a capsule of clonidine or placebo at 09:35 am
and a capsule of scopolamine or placebo at 10:35 am The different kinetic profiles of clonidine …

As determined by isoelectric focusing, most patients with familial dysbetalipoproteinemia (FD)
exhibit the homozygous apolipoprotein (apo) E2E2 phenotype. Only rarely does FD …

… The authors wish to thank Mr JA van der Zwet for breeding the tg mice and Drs AR
Wintzen, JJGM Verschuuren, RJ van den Berg and DL Ypey for valuable discussions. …

The pathophysiological mechanisms of migraine are not yet very well understood. The gene
CACNA1A, coding for the alpha 1A subunit of neuronal P/Q-type Ca2+ channels is mutated …

Febrile seizures are the most common form of convulsions between the age of 6 months and
5 years1, but genetic factors have not been identified. Here we investigated the molecular …