Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn
subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies. …

Background To reduce treatment burden and optimise patient outcomes in diabetic macular
oedema, we present 1-year results from two phase 3 trials of faricimab, a novel angiopoietin-…

Metastases are the principal cause of death in patients with cancer. Recent advances bring
hope that it will be possible to identify the molecules and processes involved in metastasis, …

The core idea of the Millennium Ecosystem Assessment is that the human condition is
tightly linked to environmental condition. This assertion suggests that conservation and …

The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen
and plays an important role in tumor cell homeostasis. We investigated the function of miR-210…

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism …

Scarring of the kidney is a major public health concern, directly promoting loss of kidney
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring in …

Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism.
MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle …

Objectives To identify a novel plasmid-mediated colistin resistance gene in Klebsiella
pneumoniae isolated from chickens in China. Methods WGS was used to identify a novel colistin …

We developed a systematic approach to map human genetic networks by combinatorial
CRISPR–Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs …