[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein substitution
D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic 1, …
D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic 1, …
[HTML][HTML] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
[HTML][HTML] Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
Interferons (IFN) are essential antiviral cytokines that establish the cellular antiviral state
through upregulation of hundreds of interferon-stimulated genes (ISGs), most of which have …
through upregulation of hundreds of interferon-stimulated genes (ISGs), most of which have …
Recent progress in henipavirus research: molecular biology, genetic diversity, animal models
B Rockx, R Winegar, AN Freiberg - Antiviral research, 2012 - Elsevier
Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses,
the henipaviruses. Both viruses have the ability to cause severe pulmonary infection …
the henipaviruses. Both viruses have the ability to cause severe pulmonary infection …
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation …
…, A Bhumkar, DJB Hunter, AN Freiberg… - Emerging microbes & …, 2021 - Taylor & Francis
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. …
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. …
[HTML][HTML] Furin cleavage site is key to SARS-CoV-2 pathogenesis
SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world.
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
A broad-spectrum antiviral targeting entry of enveloped viruses
MC Wolf, AN Freiberg, T Zhang… - Proceedings of the …, 2010 - National Acad Sciences
We describe an antiviral small molecule, LJ001, effective against numerous enveloped
viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, …
viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, …
[HTML][HTML] Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus
MF Saeed, AA Kolokoltsov, AN Freiberg… - PLoS …, 2008 - journals.plos.org
The phosphoinositide-3 kinase (PI3K) pathway regulates diverse cellular activities related to
cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires …
cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires …
[HTML][HTML] Evidence for henipavirus spillover into human populations in Africa
Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to
humans has only been reported in Australia and South/Southeast Asia. However, a recent …
humans has only been reported in Australia and South/Southeast Asia. However, a recent …
[HTML][HTML] ISG15 deficiency and increased viral resistance in humans but not mice
…, MR Rodriguez, DJ Lenschow, AN Freiberg… - Nature …, 2016 - nature.com
ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule,
intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have …
intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have …