Noninvasive characterization of Alzheimer's disease by circulating, cell-free messenger RNA next-generation sequencing

S Toden, J Zhuang, AD Acosta, AP Karns… - Science …, 2020 - science.org
The lack of accessible noninvasive tools to examine the molecular alterations occurring in
the brain limits our understanding of the causes and progression of Alzheimer’s disease (AD), …

[HTML][HTML] Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

…, AD Acosta, J Aballi, S Toden, AP Karns… - Nature …, 2020 - nature.com
Circulating cell-free mRNA (cf-mRNA) holds great promise as a non-invasive diagnostic
biomarker. However, cf-mRNA composition and its potential clinical applications remain largely …

[HTML][HTML] Survey of extracellular communication of systemic and organ-specific inflammatory responses through cell free messenger RNA profiling in mice

J Zhuang, A Ibarra, A Acosta, AP Karns, J Aballi… - Ebiomedicine, 2022 - thelancet.com
Background Inflammatory and immune responses are essential and dynamic biological
processes that protect the body against acute and chronic adverse stimuli. While conventional …

Long-Term Sustainability of Escherichia Coli Removal in Conventional Bioretention Media

…, EA Seagren, AP Davis, JS Karns - Journal of Environmental …, 2011 - ascelibrary.org
Bioretention has significant potential for reduction of bacterial levels in urban storm-water
discharge. The long-term performance of bacteria removal was evaluated using column …

Non-invasive characterization of human bone marrow by cell free messenger-RNA reveals response to growth factor stimulation and hematopoietic reconstitution after …

…, V Huang, AD Acosta, J Aballi, S Toden, AP Karns… - bioRxiv, 2019 - biorxiv.org
Circulating cell free mRNA (cf-mRNA) holds great promise as a non-invasive diagnostic
biomarker. However, the biological origin of cf-mRNA is still not well understood, limiting the …

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain …

KI Kariya, LR Karns, PC Simpson - Journal of Biological Chemistry, 1991 - Elsevier
AP-1CAT, with three collagenase AP-1 binding sequences cloned upstream from a
mouse interleukin 3 promoter (-50 to +lo) fused to the CAT gene, was a generous gift from K. …

Physician demographics and the risk of medical malpractice

MI Taragin, AP Wilczek, ME Karns, R Trout… - The American journal of …, 1992 - Elsevier
… Due to our large sample size, we required ap value of 0.01 for statistical significance.
Three additional analyses were performed to assess other potential confounders. First, we …

The critical acromial point: the anatomic location of the lateral acromion in the critical shoulder angle

MR Karns, M Jacxsens, WJ Uffmann, DC Todd… - Journal of Shoulder and …, 2018 - Elsevier
… most lateral point on the acromion, termed the CAP, which resulted in the same 3D CSA
measurement when compared with the CSA measurement on 2D images resembling true AP

High prevalence of nonalcoholic fatty liver disease in adolescents undergoing bariatric surgery

…, DE Kleiner, TW Boyce, R Mourya, R Karns… - Gastroenterology, 2015 - Elsevier
… Rebekah Karns: acquisition of data, analysis and interpretation of data, drafting and critical
revision of the manuscript for important intellectual content. Mary L. Brandt: acquisition of data…

The Capture and Destruction of Escherichia coli from Simulated Urban Runoff Using Conventional Bioretention Media and Iron Oxide‐coated Sand

…, EA Seagren, AP Davis, JS Karns - Water Environment …, 2010 - Wiley Online Library
The performance, sustainability, and mechanisms of bacterial removal from stormwater
runoff by bioretention systems are poorly understood. The potential for removal of …