[HTML][HTML] Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote

…, L Sun, G Manning, NC Elde, AP Turkewitz… - PLoS …, 2006 - journals.plos.org
… Rahaman and AP Turkewitz, unpublished data). Furthermore, phylogenetic analysis
indicated that the recruitment of dynamin to a role in endocytosis occurred independently by …

Functional genomics: the coming of age for Tetrahymena thermophila

AP Turkewitz, E Orias, G Kapler - Trends in genetics, 2002 - cell.com
Turkewitz, unpublished). Heritable transmission of the transgene to the sexual progeny
confirms that the targeting DNA molecule is integrated into the mic genome. Using linear DNA …

Out with a bang! Tetrahymena as a model system to study secretory granule biogenesis

AP Turkewitz - Traffic, 2004 - Wiley Online Library
Turkewitz, unpublished). One subset of mutants of particular interest are those in which
processing of cargo proteins is partially or entirely blocked, since these are likely to have defects …

Evolutionary cell biology: two origins, one objective

…, DS Roos, AP Turkewitz… - Proceedings of the …, 2014 - National Acad Sciences
All aspects of biological diversification ultimately trace to evolutionary modifications at the
cellular level. This central role of cells frames the basic questions as to how cells work and …

Whole‐cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila

F Amaro, AP Turkewitz… - Microbial …, 2011 - Wiley Online Library
Heavy metals are among the most serious pollutants, and thus there is a need to develop
sensitive and rapid biomonitoring methods for heavy metals in the environment. Critical …

An Alveolata secretory machinery adapted to parasite host cell invasion

…, JF Dubremetz, YW Chang, AP Turkewitz… - Nature …, 2021 - nature.com
Apicomplexa are unicellular eukaryotes and obligate intracellular parasites, including
Plasmodium (the causative agent of malaria) and Toxoplasma (one of the most widespread …

[HTML][HTML] Elucidation of Clathrin-Mediated Endocytosis in Tetrahymena Reveals an Evolutionarily Convergent Recruitment of Dynamin

…, G Morgan, M Winey, L Sperling, AP Turkewitz - PLoS …, 2005 - journals.plos.org
… sites of clathrin-dependent endocytosis and that AP-2 localizes to these sites. Unexpectedly,
… While phylogenetic analysis of AP subunits indicates a primitive origin for clathrin-mediated …

An evolutionary balance: conservation vs innovation in ciliate membrane trafficking

…, H Plattner, E Richardson, JB Dacks, AP Turkewitz - Traffic, 2017 - Wiley Online Library
As most of eukaryotic diversity lies in single‐celled protists, they represent unique opportunities
to ask questions about the balance of conservation and innovation in cell biological …

[HTML][HTML] Comprehensive Analysis Reveals Dynamic and Evolutionary Plasticity of Rab GTPases and Membrane Traffic in Tetrahymena thermophila

…, N Kambesis, SB Nelson, B Jeong, AP Turkewitz - PLoS …, 2010 - journals.plos.org
Cellular sophistication is not exclusive to multicellular organisms, and unicellular
eukaryotes can resemble differentiated animal cells in their complex network of membrane-bound …

An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma

…, S Urbach, B Striepen, AP Turkewitz… - The EMBO …, 2022 - embopress.org
Apicomplexan parasites possess secretory organelles called rhoptries that undergo regulated
exocytosis upon contact with the host. This process is essential for the parasitic lifestyle of …