Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
[PDF][PDF] Promoters recognized by forkhead proteins exist for individual 21U-RNAs
C. elegans 21U-RNAs are equivalent to the piRNAs discovered in other metazoans and have
important roles in gametogenesis and transposon control. The biogenesis and molecular …
important roles in gametogenesis and transposon control. The biogenesis and molecular …
[HTML][HTML] A Conserved PHD Finger Protein and Endogenous RNAi Modulate Insulin Signaling in Caenorhabditis elegans
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of
animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf …
animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf …
[PDF][PDF] Condensin and Hmo1 mediate a starvation-induced transcriptional position effect within the ribosomal DNA array
D Wang, A Mansisidor, G Prabhakar, A Hochwagen - Cell reports, 2016 - cell.com
Repetitive DNA arrays are important structural features of eukaryotic genomes that are often
heterochromatinized to suppress repeat instability. It is unclear, however, whether all …
heterochromatinized to suppress repeat instability. It is unclear, however, whether all …
Mechanisms of Ribosomal DNA Copy-number Regulation
A Mansisidor - 2019 - search.proquest.com
Repetitive DNA sequences are prevalent throughout the genomes of eukaryotes and are
risk factors for disease because of their inherent instability. DNA repeats also potentiate …
risk factors for disease because of their inherent instability. DNA repeats also potentiate …
[HTML][HTML] CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors
Piwi-interacting (pi) RNAs are germline-expressed small RNAs linked to epigenetic
programming. C. elegans piRNAs are thought to be transcribed as independent gene-like loci. To …
programming. C. elegans piRNAs are thought to be transcribed as independent gene-like loci. To …
Endogenous RNAi and adaptation to environment in C. elegans
A Grishok - Worm, 2012 - Taylor & Francis
The contributions of short RNAs to the control of repetitive elements are well documented in
animals and plants. Here, the role of endogenous RNAi and AF10 homolog ZFP-1 in the …
animals and plants. Here, the role of endogenous RNAi and AF10 homolog ZFP-1 in the …
[HTML][HTML] The RNase PARN-1 trims piRNA 3′ ends to promote transcriptome surveillance in C. elegans
Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and are
essential for fertility in diverse organisms. An interesting feature of piRNAs is that, while piRNA …
essential for fertility in diverse organisms. An interesting feature of piRNAs is that, while piRNA …
[PDF][PDF] The ZFP-1 (AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription
The inhibition of transcriptional elongation plays an important role in gene regulation in
metazoans, including C. elegans. Here, we combine genomic and biochemical approaches to …
metazoans, including C. elegans. Here, we combine genomic and biochemical approaches to …
[HTML][HTML] The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters
The only representative of the MYC superfamily transcription factors in C. elegans, MML-1 (Myc
and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …
and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …