… mTORC1 activity directly regulates the expression of enzymes in the PPP, while at the same
time facilitates the uptake of glucose via the Glut1 membrane transporter 79. Conversely, …

… of the hydrophobic motif of Akt at Ser473 and other kinases of the … Despite ongoing studies
aimed at delineating both upstream … To examine the expression patterns of SOCS proteins at …

… Importantly, whether γc was exclusively required at the DN … on γc expression only at the DN
stage or also at later stages. … -cKO) where γc was deleted either at the late DN stage or in pre-…

… Immune signatures of bronchoalveolar lavage (BAL) fluid in older individuals with PASC at
60–90 days post infection revealed a persistent increase in the frequency of CD69 + CD103 - …

Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4
+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and mTORC2 …

… The graph at right shows quantification of the ratio of phosphorylated to total S6 in terms of …
from at least three independent experiments (d,e) or from one experiment representative of at …

… We considered vascular endothelial cells at the BBB as likely candidates because many
types of endothelial cells express CD73 (13). However, immunohistochemistry revealed that …

… and non-redundant role in suppressing inflammation at sites of hypoxia and tissue damage.
… of tumor-antigen-specific CD8 T cells at the vaccine-site draining lymph node. Finally, we …

… We considered that ThPOK upregulated expression of at least three different SOCS-encoding
genes (Socs1, Socs3 and Cish; Fig. 1e), each of which could suppress cytokine signaling …

… at two key residues. Phosphoinositide-dependent kinase 1 (PDK1) phosphorylates Akt at
Thr308, whereas phosphorylation at … phosphorylation of Akt at Ser473 but not at Thr308, …