User profiles for A. T. Weiner

Amaro N Taylor-Weiner

- Verified email at absci.com - Cited by 21870

Alexis Thomas Weiner

- Verified email at stanford.edu - Cited by 495

[HTML][HTML] Sporadic early-onset diffuse gastric cancers have high frequency of somatic CDH1 alterations, but low frequency of somatic RHOA mutations compared with …

…, G Saksena, AD Cherniack, S Schumacher, AT Weiner… - Gastroenterology, 2017 - Elsevier
Background & Aims Early-onset gastric cancer, which develops in patients younger than
most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, …

Γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts

…, ES Milner, DJ Goetschius, AT Weiner… - Molecular biology of …, 2014 - Am Soc Cell Biol
… Because the Golgi complex can house nucleation sites, we explored whether microtubule
nucleation might occur at dendritic Golgi outposts. However, distinct Golgi outposts were not …

Patronin-mediated minus end growth is required for dendritic microtubule polarity

…, M Shorey, DY Seebold, AT Weiner… - Journal of Cell …, 2019 - rupress.org
… Adult fish were fed brine shrimp twice daily and were kept on a 14-h-light/10-h-dark cycle
at 28.5C at pH 7.5. To generate larvae for experiments, embryos were raised in glass bowls at

[HTML][HTML] Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster

…, L Pizzo, E Huber, H Koerselman, AT Weiner… - Nature …, 2018 - nature.com
… For example, seven homologs were lethal at the larval or pupal stage with ubiquitous …
We found significant differences in NMJ structure at body wall muscles 6-7 with knockdown of …

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

K Rao, MC Stone, AT Weiner, KW Gheres… - Molecular biology of …, 2016 - Am Soc Cell Biol
… et al., 2004) all localize to the ER, we hypothesized that at least a subset of HSP proteins
may contribute to axon regeneration by helping the ER concentrate at the growing axon tip. …

[HTML][HTML] Endosomal Wnt signaling proteins control microtubule nucleation in dendrites

AT Weiner, DY Seebold, P Torres-Gutierrez… - PLoS …, 2020 - journals.plos.org
at branch … at polymerizing microtubule plus ends initiated from puncta marked with fz, arr,
dsh, Axin, and Rab5. We propose that Wnt signaling proteins localize to early endosomes at

[HTML][HTML] The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons

DMR Nye, RM Albertson, AT Weiner, JI Hertzler… - PLoS …, 2020 - journals.plos.org
at branch points (Fig 9). This assay makes use of an overexpressed but functional γTubulin-GFP
[58]. In order to test whether the reduction at … a γTubulin tagged at the endogenous locus …

To nucleate or not, that is the question in neurons

AT Weiner, P Thyagarajan, Y Shen, MM Rolls - Neuroscience letters, 2021 - Elsevier
… Reduction of Rab5, but not other Rabs, reduces γ-tubulin concentration at branch points …
the MTOC at dendrite branch points in these cells. The earlier identification of Golgi markers at

Kinesin‐2 and Apc function at dendrite branch points to resolve microtubule collisions

AT Weiner, MC Lanz, DJ Goetschius… - …, 2016 - Wiley Online Library
… body at dendrite branch points. Although this model is satisfying and fits with the phenotypic
analysis, we were not able at that time to directly demonstrate that this complex functioned at

[HTML][HTML] Mitochondria and caspases tune Nmnat-mediated stabilization to promote axon regeneration

L Chen, DM Nye, MC Stone, AT Weiner… - PLoS …, 2016 - journals.plos.org
Axon injury can lead to several cell survival responses including increased stability and
axon regeneration. Using an accessible Drosophila model system, we investigated the …