Experimental IgE-mediated food allergy depends on intestinal anaphylaxis driven by
interleukin-9 (IL-9). However, the primary cellular source of IL-9 and the mechanisms underlying …

Gametogenesis is dependent on the expression of germline-specific genes. However, it
remains unknown how the germline epigenome is distinctly established from that of somatic …

… AV Kartashov and A. Barski are co-founders of Datirium, LLC. Datirium provides installation
… Barski and performed data analysis with support from AV Kartashov, X. Chen, MT Weirauch, …

Sex chromosomes are uniquely subject to chromosome-wide silencing during male meiosis,
and silencing persists into post-meiotic spermatids. Against this background, a select set of …

Pathogenic T helper 2 (T H 2) cells, which produce increased amounts of the cytokines
interleukin-5 (IL-5) and IL-13, promote allergic disorders, including asthma. Thymic stromal …

High-throughput sequencing has revolutionized biology by enhancing our ability to perform
genome-wide studies. However, due to lack of bioinformatics expertise, modern …

High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
(AHSCT) is a new and promising approach to multiple sclerosis (MS) treatment. In this …

Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains,
molecular hallmarks of developmental potential. In the male germline, these domains are …

Background The male germline transcriptome changes dramatically during the mitosis-to-meiosis
transition to activate late spermatogenesis genes and to transiently suppress genes …

Background Massive growth in the amount of research data and computational analysis has
led to increased use of pipeline managers in biomedical computational research. However, …