Although the acetylation of histones has a well-documented regulatory role in transcription
1 , 2 , 3 , 4 , its role in other chromosomal functions remains largely unexplored. Here we …

The interpretation of genome sequences requires reliable and standardized methods to assess
protein function at high throughput. Here we describe a fast and reliable pipeline to study …

… NC Hubner and AW Bird contributed equally to this paper. … be carefully analyzed in their
native context when the endogenous protein is selectively depleted (Bird and Hyman, 2008). …

… Bird: bird@mpi-cbg.de © 2008 Bird and Hyman This article is distributed under the terms of
… AW Bird has been supported by a Max Planck Society fellowship and by a Human Frontier …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine
capable of long-distance processive movement along microtubules. However, it is unclear …

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire
the synthesis of focused compound collections enriched in bioactivity. This criterion is, in …

Tpx2 is a microtubule-associated protein that activates the cell-cycle kinase Aurora A and
regulates the mitotic spindle. Overexpression of Tpx2 is associated with the development of …

The rat alpha 1-1 glutathione S-transferase (GST) contains a single, non-essential tryptophan
and only 8 tyrosines in each subunit. One of these tyrosines, Tyr-9, hydrogen bonds to the …

10.7554/eLife.23352.001 Centromeres are unique chromosomal loci that promote the
assembly of kinetochores, macromolecular complexes that bind spindle microtubules during …

Whereas bacterial artificial chromosomes (BACs) offer many advantages in studies of gene
and protein function, generation of seamless, precisely mutated BACs has been difficult. …