Gut microbiota contribute to host metabolic efficiency by increasing energy availability through
the fermentation of dietary fiber and production of short-chain fatty acids (SCFAs) in the …

Chromatin folding contributes to the regulation of genomic processes such as gene activity.
Existing conformation capture methods characterize genome topology through analysis of …

In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding
(FFPE) procedures for examination of (intra-) cellular morphology. Such …

To understand how chromatin domains coordinate gene expression, we dissected select
genetic elements organizing topology and transcription around the Prdm14 super enhancer in …

In the most intrusion detection systems (IDS), a system tries to learn characteristics of different
type of attacks by analyzing packets that sent or received in network. These packets have …

Motivation: Breast cancer outcome prediction based on gene expression profiles is an
important strategy for personalize patient care. To improve performance and consistency of …

We present the experimental protocol and data analysis toolbox for multi-contact 4C (MC-4C),
a new proximity ligation method tailored to study the higher-order chromatin contact …

Chromosomal rearrangements are important drivers in cancer, and their robust detection is
essential for diagnosis, prognosis, and treatment selection, particularly for bone and soft …

The cohesin complex (SMC1-SMC3-RAD21) shapes chromosomes by DNA loop extrusion,
but individual extrusion trajectories were so far unappreciable in vivo. Here, we site-…

Robustly predicting outcome for cancer patients from gene expression is an important
challenge on the road to better personalized treatment. Network-based outcome predictors (NOPs)…