The zebrafish larva is an optically-transparent vertebrate model with complex organs that is
widely used to study genetics, developmental biology, and to model various human diseases…

Most gene mutations and biologically active molecules cause complex responses in animals
that cannot be predicted by cell culture models. Yet animal studies remain too slow and …

Gestational diabetes mellitus (GDM) affects 3–14% of pregnancies, with 20–50% of these
women progressing to type 2 diabetes (T2D) within 5 years. This study sought to develop a …

Images can be acquired at high rates with modern fluorescence microscopy hardware,
giving rise to a demand for high-speed analysis of image data. Digital image cytometry, ie, …

Neurological drugs are often associated with serious side effects, yet drug screens typically
focus only on efficacy. We demonstrate a novel paradigm utilizing high-throughput in vivo …

Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and
young people in the Modern Era have channelled research and public health strategies to …

Background Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher
risk of developing type 2 diabetes (T2D). It is estimated that 20-50% of women with GDM …

The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription
factor II D complex that serves a vital function during transcription initiation. Variants of …

Background Exchangeable neck stems, defined as those with a dual taper (that is, a
modular junction between the femoral head and the femoral neck and an additional junction …

Context Prolactin is a multifaceted hormone known to regulate lactation. In women with
gestational diabetes mellitus (GDM) history, intensive lactation has been associated with lower …