PARP inhibitors: Synthetic lethality in the clinic

CJ Lord, A Ashworth - Science, 2017 - science.org
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the
first clinically approved drugs designed to exploit synthetic lethality, a genetic concept …

[BOOK][B] Principles of criminal law

A Ashworth, J Horder - 2013 - books.google.com
… Andrew Ashworth & Jeremy Horder … © Andrew Ashworth & Jeremy Horder 2013 The moral
rights of the authors have … Ashworth, ‘Is the Criminal Law a Lost Cause?’ (2000) 116 LQR 225. …

[BOOK][B] Sentencing and criminal justice

A Ashworth, R Kelly - 2021 - books.google.com
This revised and updated new edition focuses on major developments in sentencing law,
practice and theory. Sentencing in England and Wales is now dominated by Sentencing …

[BOOK][B] The criminal process

A Ashworth, M Redmayne - 2010 - books.google.com
The fourth edition of The Criminal Process continues in the tradition of previous editions in
providing an insightful and stimulating analysis of the key issues in criminal processes and …

Proportionate sentencing: Exploring the principles

A Von Hirsch, A Ashworth - 2005 - academic.oup.com
The principle that a sentence should be proportionate to the seriousness of the offence
remains at the centre of penal practice and scholarly debate. This book explores highly topical …

Hallmarks of'BRCAness' in sporadic cancers

N Turner, A Tutt, A Ashworth - Nature reviews cancer, 2004 - nature.com
Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer
susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-…

The DNA damage response and cancer therapy

CJ Lord, A Ashworth - Nature, 2012 - nature.com
Genomic instability is one of the most pervasive characteristics of tumour cells and is probably
the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to …

[BOOK][B] Preventive justice

A Ashworth, L Zedner - 2014 - books.google.com
This book arises from a three-year study of Preventive Justice directed by Professor Andrew
Ashworth and Professor Lucia Zedner at the University of Oxford. The study seeks to …

Responsibilities, rights and restorative justice

A Ashworth - Restorative Justice, 2017 - taylorfrancis.com
Restorative justice is much advocated as a new and fruitful response to offending. This
article argues for further debate about the proper division of functions between state, victims, …

[BOOK][B] Human rights and criminal justice

B Emmerson, A Ashworth, A Macdonald, MA Summers - 2012 - books.google.com
This work provides a full and systematic analysis of the impact of UK human rights law on
both the substantive criminal law and criminal procedure. It examines first the applicable …