Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA, …

The development of mass spectrometry-based techniques is opening new insights into the
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …

Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of fatty …

Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression 1 , 2 , but
most clinical trials with MMP inhibitors have not shown improvements in individuals with …

Proteolytic events at the cell surface are essential in the regulation of signal transduction
pathways. During the past years, the family of type II transmembrane serine proteases (TTSPs) …

Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling
processes. The finding that mice deficient in collagenase-2 (MMP-8) are more susceptible to …

The mouse ortholog of human FACE-1, Zmpste24, is a multispanning membrane protein
widely distributed in mammalian tissues 1, 2 and structurally related to Afc1p/ste24p, a yeast …

Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in the
rapid induction of lipid droplet (LD) formation by these cells. This effect appears specific for …

Our objective was to examine the association between myocardial infarction (MI) and two
DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 …

Macrophages can be activated through TLRs for a variety of innate immune responses. In
contrast with the wealth of data existing on TLR-dependent gene expression and resultant …