In animal models, immature neural precursors can replace lost neurons, restore function
and promote brain self-repair. Clinical trials in Parkinson's disease suggest that similar …

The degeneration of forebrain dopamine systems in Parkinson's disease has been an
effective target for pharmaceutical research over the past four decades. However, although …

Forum Neural transplantation in putaminal 18F-dopa uptake have also been highly variable,
which suggests that differences in survival and growth of the grafted dopaminergic neurons …

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal
mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy …

Emerging methods for the accurate quantification of gene expression in individual cells hold
promise for revealing the extent, function and origins of cell-to-cell variability. Different high-…

Single-cell gene expression analyses hold promise for characterizing cellular heterogeneity,
but current methods compromise on either the coverage, the sensitivity or the throughput. …

Recent reports demonstrate that somatic mouse cells can be directly converted to other mature
cell types by using combined expression of defined factors. Here we show that the same …

Rats sustaining unilateral near‐complete 6‐hydroxydopamine lesions of the mesostriatal
dopamine pathway received daily injections of 3,4 dihydroxyphenyl‐l‐alanine (L‐DOPA, 8 mg/…

Neural progenitor cells obtained from the embryonic human forebrain were expanded up to
10 7 -fold in culture in the presence of epidermal growth factor, basic fibroblast growth factor, …

Dying tumour cells can elicit a potent anticancer immune response by exposing the calreticulin
(CRT)/ERp57 complex on the cell surface before the cells manifest any signs of apoptosis…