The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic
cells reside. In this review, we discuss the bone marrow niches in mice that facilitate the …

Randall-type heavy chain deposition disease (HCDD) is a rare disorder characterized by
tissue deposition of a truncated monoclonal immunoglobulin heavy chain lacking the first …

Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, …

Monoclonal gammopathies are frequently complicated by kidney lesions that increase the
disease morbidity and mortality. In particular, abnormal Ig free light chains (LCs) may …

WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations.
Here we report a decrease in bone mineral density in 25% of WHIM patients and bone …

… Frédéric De Ceuninck,1 Sophie Gaufillier, Anne Bonnaud, Massimo Sabatini, Christophe
Lesur, and Philippe Pastoureau …

Long considered a homogeneous population dedicated to antibody secretion, plasma cell
phenotypic and functional heterogeneity is increasingly recognized. Plasma cells were first …

The CSH gel is an elusive material. Its variable composition and disordered nature complicate
a complete characterization of its atomic structure, and the elaboration of models is key to …

Background: The goal of this study was to examine the impact of subjective and physiological
stress responses on medical students’ diagnostic reasoning and communication skills. …

Despite the essential role of plasma cells in health and disease, the cellular mechanisms
controlling their survival and secretory capacity are still poorly understood. Here, we identified …