User profiles for A. Byrnes
Andrew P. ByrnesFood and Drug Administration Verified email at fda.hhs.gov Cited by 3468 |
[HTML][HTML] Landscape of X chromosome inactivation across human tissues
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes
in female mammalian cells to balance expression dosage between XX females and XY …
in female mammalian cells to balance expression dosage between XX females and XY …
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
We introduce an approach to identify disease-relevant tissues and cell types by analyzing
gene expression data together with genome-wide association study (GWAS) summary …
gene expression data together with genome-wide association study (GWAS) summary …
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …
but its molecular mechanisms remain poorly understood. There is some debate about …
[PDF][PDF] SynGO: an evidence-based, expert-curated knowledge base for the synapse
…, P van Nierop, M Andres-Alonso, A Byrnes… - Neuron, 2019 - cell.com
Synapses are fundamental information-processing units of the brain, and synaptic dysregulation
is central to many brain disorders ("synaptopathies"). However, systematic annotation of …
is central to many brain disorders ("synaptopathies"). However, systematic annotation of …
Immune responses to adenovirus vectors in the nervous system
…, HM Charlton, KJ Wood, K Kajiwara, AP Byrnes - Trends in …, 1996 - cell.com
Non-replicating adenovirus vectors are being developed as vehicles for gene transfer into
cells of the nervous system. An important requirement for successful gene transfer is the …
cells of the nervous system. An important requirement for successful gene transfer is the …
Modeling dielectric-constant values of geologic materials: An aid to ground-penetrating radar data collection and interpretation
A Martinez, AP Byrnes - Current Research in Earth Sciences, 2001 - journals.ku.edu
Ground-penetrating radar (GPR) is a near-surface geophysical imaging technique used for
non-intrusive subsurface geologic and engineering investigations. Dielectric constant is a …
non-intrusive subsurface geologic and engineering investigations. Dielectric constant is a …
Binding of Sindbis virus to cell surface heparan sulfate
AP Byrnes, DE Griffin - Journal of Virology, 1998 - Am Soc Microbiol
Alphaviruses are arthropod-borne viruses with wide species ranges and diverse tissue
tropisms. The cell surface receptors which allow infection of so many different species and cell …
tropisms. The cell surface receptors which allow infection of so many different species and cell …
Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine
SK Libutti, GF Paciotti, AA Byrnes, HR Alexander Jr… - Clinical cancer …, 2010 - AACR
Purpose: A novel nanomedicine, CYT-6091, constructed by simultaneously binding recombinant
human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol to the …
human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol to the …
The clinical use of karyotyping spontaneous abortions
WA Hogge, AL Byrnes, MC Lanasa, U Surti - American journal of obstetrics …, 2003 - Elsevier
OBJECTIVE: The objective of this study was to assess the clinical use of routinely karyotyping
spontaneous abortion material. STUDY DESIGN: We retrospectively reviewed the records …
spontaneous abortion material. STUDY DESIGN: We retrospectively reviewed the records …
Interaction of adenovirus with antibodies, complement, and coagulation factors
RJ Allen, AP Byrnes - FEBS letters, 2019 - Wiley Online Library
Adenovirus (AdV) is one of the most widely used vectors for gene therapy and vaccine studies
due to its excellent transduction efficiency, capacity for large transgenes, and high levels …
due to its excellent transduction efficiency, capacity for large transgenes, and high levels …