There has been considerable literature over the last 20 years surrounding adaptive methods
of mesh refinement, or solution improvement, in the finite element method. Publications …

The first wave of information from the analysis of the human genome revealed SNPs to be
the main source of genetic and phenotypic human variation. However, the advent of genome-…

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among young adults.
Substance abusers constitute a disproportionate percentage of these patients. A history of …

Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of
multiple TNF receptors and receptors that induce interferon-α (IFN-α), IFN-β, and IFN-λ …

Herpes simplex encephalitis (HSE) is the most common sporadic viral encephalitis of childhood.
Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (…

Childhood herpes simplex virus-1 (HSV-1) encephalitis (HSE) may result from single-gene
inborn errors of TLR3 immunity. TLR3-dependent induction of IFN-α/β or IFN-λ is crucial for …

Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be
fully ascertained. We have constructed a first-generation CNV map of the human genome …

The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments
in reciprocal social interaction and communication, and the presence of restricted and …

Background Concerns regarding potential neurological complications of COVID-19 are being
increasingly reported, primarily in small series. Larger studies have been limited by both …

Objective: To evaluate the phenotypic spectrum associated with mutations in TBC1D24.
Methods: We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported …