Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the
Observatory is to collect unprecedented information about cosmic rays above 10 18 eV . The …

The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It
combines a surface array to measure secondary particles at ground level together with a …

Background A polypill that includes key medications associated with improved outcomes (aspirin,
angiotensin-converting–enzyme [ACE] inhibitor, and statin) has been proposed as a …

Objectives Initial data on COVID-19 infection has pointed out a special vulnerability of older
adults. Design We performed a meta-analysis with available national reports on May 7, 2020 …

Emotional states influence bodily physiology, as exemplified in the top-down process by which
anxiety causes faster beating of the heart 1 , 2 – 3 . However, whether an increased heart …

Background: The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a
risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-…

A widespread approach to modern cancer therapy is to identify a single oncogenic driver
gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-…

As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …

Background: Childhood asthma has become a critical public health problem because of its
high morbidity and increasing prevalence. The impact of nutrition and other exposures during …

Some variants of Newton’s method are developed in this work in order to solve nonlinear
equations depending on one or several variables, based in rules of quadrature of fifth order. …