Success and failure of 50 innovation projects in Dutch companies

AJ Cozijnsen, WJ Vrakking… - European Journal of …, 2000 - emerald.com
Continued innovation of products, services, technology and the organization itself, is one way
to keep a business on its feet during these turbulent times. The importance of innovation – …

[HTML][HTML] Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

…, V Anthouard, P Bally, S Bourras, AJ Cozijnsen… - Nature …, 2011 - nature.com
Fungi are of primary ecological, biotechnological and economic importance. Many fundamental
biological processes that are shared by animals and fungi are studied in fungi due to …

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans

DM Gardiner, AJ Cozijnsen, LM Wilson… - Molecular …, 2004 - Wiley Online Library
Sirodesmin PL is a phytotoxin produced by the fungus Leptosphaeria maculans, which
causes blackleg disease of canola (Brassica napus). This phytotoxin belongs to the …

[HTML][HTML] Evolution of Linked Avirulence Effectors in Leptosphaeria maculans Is Affected by Genomic Environment and Exposure to Resistance Genes in Host Plants

AP Van de Wouw, AJ Cozijnsen, JK Hane… - PLoS …, 2010 - journals.plos.org
Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria
maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are …

[PDF][PDF] Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection

…, A Zaid, YC Wong, LS Lau, V Mollard, A Cozijnsen… - Immunity, 2016 - cell.com
In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

…, M Matsuzaki, T Toyama, A Sturm, A Cozijnsen… - Science, 2016 - science.org
Drug resistance compromises control of malaria. Here, we show that resistance to a commonly
used antimalarial medication, atovaquone, is apparently unable to spread. Atovaquone …

Voicing by adapting and innovating employees: An empirical study on how personality and environment interact to affect voice behavior

O Janssen, T De Vries, AJ Cozijnsen - Human Relations, 1998 - journals.sagepub.com
This article reports two studies exploring how cognitive style preferences for adaption-innovation
affect the likelihood that employees will voice ideas for organizational change toward …

[HTML][HTML] Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes

NJ Patron, RF Waller, AJ Cozijnsen, DC Straney… - BMC Evolutionary …, 2007 - Springer
Background Genes responsible for biosynthesis of fungal secondary metabolites are
usually tightly clustered in the genome and co-regulated with metabolite production. …

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

A Sturm, V Mollard, A Cozijnsen… - Proceedings of the …, 2015 - National Acad Sciences
Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyruvate derived from
glycolysis. Blood-stage malaria parasites eschew chemiosmosis, instead relying almost solely …

mRNA vaccine against malaria tailored for liver-resident memory T cells

…, BJ Compton, AJ Marshall, A Cozijnsen… - Nature …, 2023 - nature.com
Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …