Background Myelodysplastic syndromes are a diverse and common group of chronic
hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and …

Single-cell RNA sequencing (scRNA-seq) has become an established and powerful method
to investigate transcriptomic cell-to-cell variation, thereby revealing new cell types and …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is
characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these …

Introduction Blood production in humans culminates in the daily release of around 10 11
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …

Regulation of hematopoiesis during human development remains poorly defined. Here we
applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-…

Hematopoietic differentiation critically depends on combinations of transcriptional
regulators controlling the development of individual lineages. Here, we report the genome-wide …

Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

The ontogeny of the human haematopoietic system during fetal development has previously
been characterized mainly through careful microscopic observations 1 . Here we …

Probing cellular population diversity at single-cell resolution became possible only in recent
years. The popularity of single-cell ‘omic’ approaches, which allow researchers to dissect …