The GC content of bacterial genomes varies from 25 to 75%, but the reason for this variation
is unclear. Here, we show that genomes of bacteria that rely on their host for survival (…

The specificity of synapses in the mammalian brain cannot possibly be accounted for by one-to-one
biochemical matching. The alternative proposed in this article is that connections are …

Living organisms are composed of macromolecules made of hydrogen, carbon, nitrogen,
oxygen, phosphorus and sulfur. Much work has been devoted to the metabolism of the first five …

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we
carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the …

The Escherichia coli species represents one of the best-studied model organisms, but also
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …

Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen.
The complete genome sequence of strain TT01 is 5,688,987 base pairs (bp) long and …

The genomic sequences of severe acute respiratory syndrome coronaviruses from human
and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly …

Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes
with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In …

The calmodulin‐sensitive adenylate cyclase of Bordetella pertussis, a 45 kd secreted protein,
is synthesized as a 1706 amino acid precursor. We have shown that this precursor is a …

A considerable fraction of life develops in the sea at temperatures lower than 15C. Little is
known about the adaptive features selected under those conditions. We present the analysis …