How do adverse childhood experiences get ‘under the skin’ and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

Background Although many meta-analyses have examined the association between childhood
sexual abuse and subsequent outcomes, the scope, validity, and quality of this evidence …

Obesity is a prevalent global-health problem associated with substantial morbidity, impairment
and economic burden. Because most readily available forms of treatment are ineffective …

Objective To understand why children exposed to adverse psychosocial experiences are at
elevated risk for age-related disease, such as cardiovascular disease, by testing whether …

Antiaging therapies show promise in model organism research. Translation to humans is
needed to address the challenges of an aging global population. Interventions to slow human …

BackgroundRates of depression have been rising, as have rates of work stress. We tested
the influence of work stress on diagnosed depression and anxiety in young working adults.…

… 20 Danese A, van Harmelen AL. The hidden wounds of childhood trauma. Eur J
Psychotraumatol 2017;8(supp 5):137584. … 54 Danese A, Widom CS. Objective and …

Importance Mental health professionals typically encounter patients at 1 point in patients’
lives. This cross-sectional window understandably fosters focus on the current presenting …

Background Adverse childhood experiences ( ACE s; eg abuse, neglect, and parental loss)
have been associated with increased risk for later‐life disease and dysfunction using adults’ …

Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …