The pivotal role of kinases in signal transduction and cellular regulation has lent them
considerable appeal as pharmacological targets across a broad spectrum of cancers. p21-…

Modulation of pathological angiogenesis by curcumin (diferuloylmethane), the active principle
of turmeric, seems to be an important possibility meriting mechanistic investigations. In …

Transcription, splicing, and translation are potentially coordinately regulatable in a
temporospatial-dependent manner, although supporting experimental evidence for this notion is …

The value of broadening searches for data across multiple repositories has been identified
by the biomedical research community. As part of the US National Institutes of Health (NIH) …

Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor
of estrogen receptor α (ERα), as a transcriptional activator of Breast Cancer Amplified …

Today’s science increasingly requires effective ways to find and access existing datasets
that are distributed across a range of repositories. For researchers in the life sciences, …

Selective estrogen receptor (ER) modulators have been the most commonly used neoadjuvant
therapy for hormone-dependent breast cancer. However, resistance to endocrine therapy…

Objective Finding relevant datasets is important for promoting data reuse in the biomedical
domain, but it is challenging given the volume and complexity of biomedical data. Here we …

The RET proto-oncogene, a tyrosine kinase receptor, is widely known for its essential role in
cell survival. Germ line missense mutations, which give rise to constitutively active …

Objective In recognition of potential barriers that may inhibit the widespread adoption of
biomedical software, the 2014 i2b2 Challenge introduced a special track, Track 3 – Software …