Levels of residual structure in disordered interaction domains determine in vitro binding
affinities, but whether they exert similar roles in cells is not known. Here, we show that increasing …

Background RNA-binding proteins (RBPs) mediate mRNA biogenesis, translation and
decay. We recently developed an approach to profile transcriptome-wide RBP contacts on …

A functional DNA damage response is essential for maintaining genome integrity in the
presence of DNA double-strand breaks. It is mainly coordinated by the kinases ATM, ATR, and …

Cellular signaling systems precisely transmit information in the presence of molecular noise
while retaining flexibility to accommodate the needs of individual cells. To understand …

TiO 2 films were grown by ion beam sputter deposition under systematic variation of ion beam
parameters (ion species, ion energy) and geometrical parameters (ion incidence angle, …

Discontinuous transcription has been described for different mammalian cell lines and
numerous promoters. However, our knowledge of how the activity of individual promoters is …

Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial
step in metastasis, which is largely responsible for the poor prognosis of small-cell lung …

Molecular profiling and functional assessment of signalling pathways of advanced solid
tumours are becoming increasingly available. However, their clinical utility in guiding patients’ …

Ion beam sputter deposition (IBSD) is an established physical vapour deposition technique
that offers the opportunity to tailor the properties of film-forming particles and, consequently, …

Silatranes are pentacoordinate silicon derivatives formed from the reaction of trialkanolamines
such as triethanolamine with trifunctional silanes such as RSi (OMe) 3. This paper …