The scientific framework concerning estrogen effects on different tissues has expanded
enormously during the last decades, when estrogen receptor (ER) subtypes were identified. …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of somatic …

Hepatic progenitor cells are bi-potential stem cells residing in human and animal livers that
are able to differentiate towards the hepatocytic and the cholangiocytic lineages. In adult …

The microvascular supply of the biliary tree, the peribiliary plexus (PBP), stems from the hepatic
artery branches and flows into the hepatic sinusoids. A detailed three-dimensional study …

BACKGROUND.: The alpha isotype of actin expressed by hepatic stellate cells reflects their
activation to myofibroblast-like cell and has been directly related to experimental liver …

Stem/progenitors have been identified intrahepatically in the canals of Hering and extrahepatically
in glands of the biliary tree. Glands of the biliary tree (peribiliary glands) are tubulo‐…

Background & Aims: Vascular endothelial growth factor (VEGF) is secreted by several
epithelia and modulates cellular functions by autocrine and paracrine mechanisms. The role of …

Hepatic progenitor cells (HPCs) play a major role in liver repair and regeneration. We evaluated
HPC involvement in pediatric nonalcoholic fatty liver disease (pNAFLD). Thirty biopsies …

We investigated the expression of estrogen receptors (ERs), insulin-like growth factor 1 (IGF-1),
and IGF-1R (receptor) in human cholangiocarcinoma and cholangiocarcinoma cell lines (…

Background & Aims : We investigated the expression of estrogen receptor (ER) α and β
subtypes in cholangiocytes of normal and bile duct–ligated (BDL) rats and evaluated the role …