The yeast Saccharomyces cerevisiae is a powerful model system to understand the molecular
basis of aging. It has been known for over 50 years that yeast cells have a finite replicative …

Repeat families within genomes are often maintained with similar sequences. Traditionally,
this has been explained by concerted evolution, where repeats in an array evolve “in concert…

Organisms maintain ribosomal RNA gene repeats (rDNA) at stable copy numbers by
recombination; the loss of repeats results in gene amplification. Here we report a mechanism of …

We sequenced and compared the genomes of the Dothideomycete fungal plant pathogens
Cladosporium fulvum (Cfu) (syn. Passalora fulva) and Dothistroma septosporum (Dse) that …

This study attempts to resolve relationships among and within the four basal arthropod lineages
(Pancrustacea, Myriapoda, Euchelicerata, Pycnogonida) and to assess the widespread …

In eukaryotes, the ribosomal DNA (rDNA) consists of long tandem repeat arrays. These
repeated genes are unstable because homologous recombination between them results in copy …

Chytridiomycosis is a recently identified fungal disease associated with global population
declines of frogs. Although the fungus, Batrachochytrium dendrobatidis, is considered an …

Polyploidy—the increase in the number of whole chromosome sets—is an important evolutionary
force in eukaryotes. Polyploidy is well recognized throughout the evolutionary history …

The short arms of the five acrocentric human chromosomes harbor sequences that direct
the assembly and function of the nucleolus, one of the key functional domains of the nucleus, …

Genomic instability is a conserved factor in lifespan reduction, although the molecular
mechanism is not known [1]. Studies in the yeast Saccharomyces cerevisiae over the past 20 …