In mammalian cells, the nuclear export receptor, Exportin 5 (Exp5), exports pre-microRNAs (pre-miRNAs)
as well as tRNAs into the cytoplasm. In this study, we examined the function of …

The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the
medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons …

Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are
mediated by glutamatergic and GABAergic signaling. Using a 60-channel perforated multi-…

In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally
targeted strategies such as surgical resection or the modulation of the activity of specific …

Network hyperexcitability is a feature of Alzheimer’ disease (AD) as well as numerous
transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models …

Excessive synchronous neuronal activity is a defining feature of epileptic activity. We
previously characterized the properties of distinct glutamatergic and GABAergic transmission-…

Background The use of nicotinic agonists for analgesia is limited by their unacceptable side
effects. Sazetidine-A is a new partial agonist nicotinic ligand that has very high selectivity for …

Dynamin-1 is a large GTPase with an obligatory role in synaptic vesicle endocytosis at
mammalian nerve terminals. Heterozygous missense mutations in the dynamin-1 gene (DNM1) …

Hypothermia can terminate epileptiform discharges in vitro and in vivo epilepsy models.
Hypothermia is becoming a standard treatment for brain injury in infants with perinatal hypoxic …