Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …

Adenovirus based vectors are of increasing importance for wide ranging therapeutic applications.
As vaccines, vectors derived from human adenovirus species D serotypes 26 and 48 (…

CD4 + T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 …

Isolation of peptide-specific T-cell clones is highly desirable for determining the role of T-cells
in human disease, as well as for the development of therapies and diagnostics. However, …

The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T cells
to control tumor growth. In this study, we performed an unbiased comparison of the TME of …

Immune checkpoint inhibitors (antibodies that block the T cell co‐inhibitory receptors PD‐1/PD‐L1
or CTLA‐4) have revolutionized the treatment of some forms of cancer. Importantly, …

T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated
by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals …

Deep learning models have been shown to accurately predict protein structure from sequence,
allowing researchers to explore protein space from the structural viewpoint. In this paper …

The oncofoetal antigen 5T4 is a promising T cell target in the context of colorectal cancer, as
demonstrated by a recent clinical study where 5T4-specific T cell responses, induced by …

CD4 + T-cells recognize peptide antigens, in the context of human leukocyte antigen (HLA)
class II molecules (HLA-II), which through peptide-flanking residues (PFRs) can extend …