An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species
The molecular codes underpinning the functions of plant NLR immune receptors are poorly
understood. We used in vitro Mu transposition to generate a random truncation library and …
understood. We used in vitro Mu transposition to generate a random truncation library and …
[HTML][HTML] Fighting antimicrobial resistance: development and implementation of the Ghanaian national action plan (2017–2021)
In recent years, Ghana has been recognised as a leading player in addressing antimicrobial
resistance (AMR) in Africa. However, based on our literature review, we could not ascertain …
resistance (AMR) in Africa. However, based on our literature review, we could not ascertain …
[HTML][HTML] Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries
J Patel, A Harant, G Fernandes… - The Lancet Infectious …, 2023 - thelancet.com
Background Understanding strategic commitments and policy responses to overcome
antimicrobial resistance at the national, regional, and global levels is required to evaluate current …
antimicrobial resistance at the national, regional, and global levels is required to evaluate current …
NLR immune receptor–nanobody fusions confer plant disease resistance
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security.
Efforts to retool the plant immune system have been limited to modifying natural …
Efforts to retool the plant immune system have been limited to modifying natural …
[HTML][HTML] An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana
H Adachi, T Sakai, A Harant, H Pai, K Honda… - PLoS …, 2023 - journals.plos.org
The NRC immune receptor network has evolved in asterid plants from a pair of linked genes
into a genetically dispersed and phylogenetically structured network of sensor and helper …
into a genetically dispersed and phylogenetically structured network of sensor and helper …
Resurrection of plant disease resistance proteins via helper NLR bioengineering
Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich
repeat (NLR) proteins that function as central nodes in immune receptor networks. …
repeat (NLR) proteins that function as central nodes in immune receptor networks. …
[HTML][HTML] The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4
J Kourelis, MP Contreras, A Harant, H Pai… - PLoS …, 2022 - journals.plos.org
Cell surface pattern recognition receptors (PRRs) activate immune responses that can
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …
[HTML][HTML] Assessing transparency and accountability of national action plans on antimicrobial resistance in 15 African countries
A Harant - Antimicrobial Resistance & Infection Control, 2022 - Springer
Background Antimicrobial resistance (AMR) poses an increasing public health threat to low-
and lower-middle income countries. Recent studies found that in fact poor governance and …
and lower-middle income countries. Recent studies found that in fact poor governance and …
[HTML][HTML] Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus
T Langner, A Harant, LB Gomez-Luciano… - PLoS …, 2021 - journals.plos.org
Supernumerary mini-chromosomes–a unique type of genomic structural variation–have
been implicated in the emergence of virulence traits in plant pathogenic fungi. However, the …
been implicated in the emergence of virulence traits in plant pathogenic fungi. However, the …
[HTML][HTML] Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus
Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here,
we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa …
we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa …