An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

H Adachi, MP Contreras, A Harant, C Wu, L Derevnina… - Elife, 2019 - elifesciences.org
The molecular codes underpinning the functions of plant NLR immune receptors are poorly
understood. We used in vitro Mu transposition to generate a random truncation library and …

[HTML][HTML] Fighting antimicrobial resistance: development and implementation of the Ghanaian national action plan (2017–2021)

W Hein, LM Aglanu, MD Mensah-Sekyere, A Harant… - Antibiotics, 2022 - mdpi.com
In recent years, Ghana has been recognised as a leading player in addressing antimicrobial
resistance (AMR) in Africa. However, based on our literature review, we could not ascertain …

[HTML][HTML] Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries

J Patel, A Harant, G Fernandes… - The Lancet Infectious …, 2023 - thelancet.com
Background Understanding strategic commitments and policy responses to overcome
antimicrobial resistance at the national, regional, and global levels is required to evaluate current …

NLR immune receptor–nanobody fusions confer plant disease resistance

J Kourelis, C Marchal, A Posbeyikian, A Harant… - Science, 2023 - science.org
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security.
Efforts to retool the plant immune system have been limited to modifying natural …

[HTML][HTML] An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana

H Adachi, T Sakai, A Harant, H Pai, K Honda… - PLoS …, 2023 - journals.plos.org
The NRC immune receptor network has evolved in asterid plants from a pair of linked genes
into a genetically dispersed and phylogenetically structured network of sensor and helper …

Resurrection of plant disease resistance proteins via helper NLR bioengineering

…, C Duggan, ELH Yuen, CEM Stevenson, A Harant… - Science …, 2023 - science.org
Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich
repeat (NLR) proteins that function as central nodes in immune receptor networks. …

[HTML][HTML] The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4

J Kourelis, MP Contreras, A Harant, H Pai… - PLoS …, 2022 - journals.plos.org
Cell surface pattern recognition receptors (PRRs) activate immune responses that can
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …

[HTML][HTML] Assessing transparency and accountability of national action plans on antimicrobial resistance in 15 African countries

A Harant - Antimicrobial Resistance & Infection Control, 2022 - Springer
Background Antimicrobial resistance (AMR) poses an increasing public health threat to low-
and lower-middle income countries. Recent studies found that in fact poor governance and …

[HTML][HTML] Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

T Langner, A Harant, LB Gomez-Luciano… - PLoS …, 2021 - journals.plos.org
Supernumerary mini-chromosomes–a unique type of genomic structural variation–have
been implicated in the emergence of virulence traits in plant pathogenic fungi. However, the …

[HTML][HTML] Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus

…, AJ Foster, T Langner, A Malmgren, A Harant… - PLoS …, 2023 - journals.plos.org
Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here,
we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa …