Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression

A Hochheimer, R Tjian - Genes & development, 2003 - genesdev.cshlp.org
Transcription initiation is a key regulatory step in the control of gene expression. Formation
of a preinitiation complex at the right time and at the right promoter is a prerequisite to …

[PDF][PDF] The convergence of stem cell technologies and phenotypic drug discovery

A Friese, A Ursu, A Hochheimer, HR Schöler… - Cell Chemical …, 2019 - cell.com
Recent advances in induced pluripotent stem cell technologies and phenotypic screening
shape the future of bioactive small-molecule discovery. In this review we analyze the impact of …

TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila

A Hochheimer, S Zhou, S Zheng, MC Holmes, R Tjian - Nature, 2002 - nature.com
Drosophila TATA-box-binding protein (TBP)-related factor 2 (TRF2) is a member of a family
of TBP-related factors present in metazoan organisms. Recent evidence suggests that TRF2s …

[HTML][HTML] Drug repurposing: the anthelmintics niclosamide and nitazoxanide are potent TMEM16A antagonists that fully bronchodilate airways

…, K Kunzelmann, D Mohn, A Hochheimer… - Frontiers in …, 2019 - frontiersin.org
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. …

Transcription of histone gene cluster by differential core-promoter factors

…, S Keles, M Prestel, A Hochheimer… - Genes & …, 2007 - genesdev.cshlp.org
The 100 copies of tandemly arrayed Drosophila linker (H1) and core (H2A/B and H3/H4)
histone gene cluster are coordinately regulated during the cell cycle. However, the molecular …

Function of H2-forming methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum in coenzyme F420 reduction with H2

C Afting, A Hochheimer, RK Thauer - Archives of microbiology, 1998 - Springer
In most methanogenic archaea, two hydrogenase systems that can catalyze the reduction of
coenzyme F 420 (F 420 ) with H 2 are present: (1) the F 420 -reducing hydrogenase, which …

The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum …

A Hochheimer, R Hedderich, RK Thauer - Archives of microbiology, 1998 - Springer
Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO
2 in methanogenic archaea. Methanobacterium wolfei and Methanobacterium …

The Tungsten Formylmethanofuran Dehydrogenase from Methanobacterium Thermoautotrophicum Contains Sequence Motifs Characteristic for Enzymes Containing …

A Hochheimer, RA Schmitz, RK Thauer… - European journal of …, 1995 - Wiley Online Library
Formylmethanofuran dehydrogenases are molybdenum or tungsten iron‐sulfur proteins
containing a pterin dinucleotide cofactor. We report here on the primary structures of the four …

Regulation of the synthesis of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) and of HmdII and HmdIII in Methanothermobacter marburgensis

C Afting, E Kremmer, C Brucker, A Hochheimer… - Archives of …, 2000 - Springer
Recently it was found that the specific activity of H 2 -forming methylenetetrahydromethanopterin
dehydrogenase (Hmd) in Methanothermobacter marburgensis (formerly …

The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes

CJ Wippo, L Israel, S Watanabe, A Hochheimer… - The EMBO …, 2011 - embopress.org
Nucleosomes impede access to DNA. Therefore, nucleosome positioning is fundamental to
genome regulation. Nevertheless, the molecular nucleosome positioning mechanisms are …