This article provides a comprehensive review of the global monsoon that encompasses
findings from studies of both modern monsoons and paleomonsoons. We introduce a definition …

Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating
osteogenic differentiation and bone formation. Thus far, no study has established the …

Background: Anorectal malformations represent a continuing challenge for the pediatric
surgeon. A significant number of these children suffer from fecal incontinence, urinary …

Advances in the treatment of metastatic melanoma have improved responses and survival.
However, many patients continue to experience resistance or toxicity to treatment, …

Resistance exercise training (RET) remains the most effective treatment for the loss of
muscle mass and strength in elderly people. However, the underlying cellular and molecular …

The scarcity of usable nitrogen frequently limits plant growth. A tight metabolic association
with rhizobial bacteria allows legumes to obtain nitrogen compounds by bacterial reduction of …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

BRAF inhibitors elicit rapid antitumor responses in the majority of patients with BRAF V600 -mutant
melanoma, but acquired drug resistance is almost universal. We sought to identify the …

The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting
human apolipoprotein B-100 (apoB-100)], was characterized in mouse, rat, monkey, …

Clinically acquired resistance to MAPK inhibitor (MAPKi) therapies for melanoma cannot be
fully explained by genomic mechanisms and may be accompanied by co-evolution of intra-…