Where the crossovers are: recombination distributions in mammals

L Kauppi, AJ Jeffreys, S Keeney - Nature Reviews Genetics, 2004 - nature.com
Until recently, recombination studies in humans and mice had identified only a few anecdotal
examples of crossover hot spots. Recently, the pace of discovery has accelerated. In every …

Individual-specific 'fingerprints' of human DNA

AJ Jeffreys, V Wilson, SL Thein - Nature, 1985 - nature.com
Simple tandem-repetitive regions of DNA (or ‘minisatellites’) which are dispersed in the
human genome frequently show substantial length polymorphism arising from unequal …

Hypervariable 'minisatellite'regions in human DNA

AJ Jeffreys, V Wilson, SL Thein - Nature, 1985 - nature.com
The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected
via a shared 10–15-base pair ‘core’ sequence similar to the generalized recombination …

Forensic application of DNA 'fingerprints'

P Gill, AJ Jeffreys, DJ Werrett - Nature, 1985 - nature.com
Many highly polymorphic minisatellite loci can be detected simultaneously in the human
genome by hybridization to probes consisting of tandem repeats of the ‘core’ sequence 1 . The …

Positive identification of an immigration test-case using human DNA fingerprints

AJ Jeffreys, JFY Brookfield, R Semeonoff - Nature, 1985 - nature.com
The human genome contains a set of minisatellites, each of which consists of tandem
repeats of a DNA segment containing the ‘core’ sequence, a putative recombination signal in …

[HTML][HTML] Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

M Blagojevic, C Jinks, A Jeffery, KP Jordan - Osteoarthritis and cartilage, 2010 - Elsevier
OBJECTIVE: Knee osteoarthritis (OA) is common in older adults. Determination of risk factors
for onset of knee OA may help in its prevention. The objective of this systematic review, and …

Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex

AJ Jeffreys, L Kauppi, R Neumann - Nature genetics, 2001 - nature.com
There is considerable interest in understanding patterns of linkage disequilibrium (LD) in the
human genome, to aid investigations of human evolution and facilitate association studies …

[HTML][HTML] Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

…, D Jyothi, L Amenga-Etego, C Hubbart, A Jeffreys… - Nature, 2012 - nature.com
Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA

AJ Jeffreys, NJ Royle, V Wilson, Z Wong - Nature, 1988 - nature.com
Tandem-repetitive minisatellite regions in vertebrate DNA frequently show substantial allelic
variation in the number of repeat units. This variation is thought to arise through processes …

Human minisatellite mutation rate after the Chernobyl accident

…, VA Ostapenko, R Neumann, DL Neil, AJ Jeffreys - Nature, 1996 - nature.com
Germline mutation at human minisatellite loci has been studied among children born in
heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a …