DNA methylation is a stable but not irreversible epigenetic signal that silences gene expression.
It has a variety of important functions in mammals, including control of gene expression, …

More than 3000 type II restriction endonucleases have been discovered. They recognize
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg 2+ , cleave the …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation after
DNA replication. Evidence suggests that the protein is located at the replication fork, where …

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …

DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐L‐methionine
to cytosine or adenine bases in DNA. These enzymes challenge the Watson/Crick …

Using peptide arrays and binding to native histone proteins, we show that the ADD domain
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di- and …

The mammalian DNA methyltransferase Dnmt1 is responsible for the maintenance of the
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …

By methylation of peptide arrays, we determined the specificity profile of the protein
methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is …

Dnmt3L has been identified as a stimulator of the catalytic activity of de novo DNA
methyltransferases. It is essential in the development of germ cells in mammals. We show here that …