Proliferating cell nuclear antigen (PCNA) protein is one of the central molecules responsible
for decisions of life and death of the cell. The PCNA gene is induced by p53, while PCNA …

The ultimate goal of structural biology is to understand the structural basis of proteins in
cellular processes. In structural biology, the most critical issue is the availability of high-quality …

The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins
to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. …

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and
cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the …

The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made
of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. …

The crystal structure of the trp repressor/operator complex shows an extensive contact surface,
including 24 direct and 6 solvent-mediated hydrogen bonds to the phosphate groups of …

The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …

Protein X-ray crystallography recently celebrated its 50th anniversary. The structures of
myoglobin and hemoglobin determined by Kendrew and Perutz provided the first glimpses into …

The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic
health crisis. An attractive target for antiviral inhibitors is the main protease 3CL M pro due to …

The structure of the I domain of integrin αLβ2 bound to the Ig superfamily ligand ICAM-1 reveals
the open ligand binding conformation and the first example of an integrin-IgSF interface. …