User profiles for A. Khayachi
 | Anouar KhayachiMcGill University Verified email at mcgill.ca Cited by 421 |
Epigenetics in bipolar disorder: a critical review of the literature
A Legrand, A Iftimovici, A Khayachi… - Psychiatric …, 2021 - journals.lww.com
Methods We searched PubMed, and Embase databases and classified the articles
depending on the epigenetic mechanisms (DNA methylation, histone modifications and non-coding …
depending on the epigenetic mechanisms (DNA methylation, histone modifications and non-coding …
Posttranslational modifications & lithium's therapeutic effect—Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders
Several neurodegenerative diseases and neuropsychiatric disorders display aberrant
posttranslational modifications (PTMs) of one, or many, proteins. Lithium treatment has been used …
posttranslational modifications (PTMs) of one, or many, proteins. Lithium treatment has been used …
[HTML][HTML] Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
A Khayachi, C Gwizdek, G Poupon, D Alcor… - Nature …, 2018 - nature.com
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and
the best-studied monogenic cause of autism. FXS results from the functional absence of the …
the best-studied monogenic cause of autism. FXS results from the functional absence of the …
[HTML][HTML] Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice
…, S Castagnola, M Chafai, A Khayachi… - Nature …, 2021 - nature.com
Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and the
best-described monogenic cause of autism. CGG-repeat expansion in the FMR1 gene …
best-described monogenic cause of autism. CGG-repeat expansion in the FMR1 gene …
Activity‐dependent regulation of the sumoylation machinery in rat hippocampal neurons
C Loriol, A Khayachi, G Poupon, C Gwizdek… - Biology of the …, 2013 - Wiley Online Library
Background information Sumoylation is a key post‐translational modification by which the
Small Ubiquitin‐like MOdifier (SUMO) polypeptide is covalently attached to specific lysine …
Small Ubiquitin‐like MOdifier (SUMO) polypeptide is covalently attached to specific lysine …
Involvement of phosphodiesterase 2A activity in the pathophysiology of fragile X syndrome
…, L Castro, L Costa, S Delhaye, A Khayachi… - Cerebral …, 2019 - academic.oup.com
The fragile X mental retardation protein (FMRP) is an RNA-binding protein involved in
translational regulation of mRNAs that play key roles in synaptic morphology and plasticity. The …
translational regulation of mRNAs that play key roles in synaptic morphology and plasticity. The …
Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons
A Khayachi, A Ase, C Liao, A Kamesh… - Journal of Psychiatry and …, 2021 - jpn.ca
Background: Bipolar disorder is characterized by cyclical alternation between mania and
depression, often comorbid with psychosis and suicide. Compared with other medications, the …
depression, often comorbid with psychosis and suicide. Compared with other medications, the …
[HTML][HTML] Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How
proteostasis is controlled independently for each type of synaptic protein in a synapse-…
proteostasis is controlled independently for each type of synaptic protein in a synapse-…
In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin
C Devader, A Khayachi, J Veyssiere… - British journal of …, 2015 - Wiley Online Library
Background and Purpose We have described a novel antidepressant peptide, spadin, that
acts by blocking the TWIK ‐related‐potassium channel, type 1 ( TREK ‐1). Here, we …
acts by blocking the TWIK ‐related‐potassium channel, type 1 ( TREK ‐1). Here, we …
[HTML][HTML] USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
L Schorova, N Bedard, A Khayachi, HH Ho… - npj Parkinson's …, 2023 - nature.com
The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD),
interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the …
interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the …