User profiles for A. Kolodziejczyk

Aleksandra A Kolodziejczyk

- Verified email at iimcb.gov.pl - Cited by 8095

Aleksandra Kolodziejczyk

- Verified email at dfci.harvard.edu - Cited by 770

Dysbiosis and the immune system

M Levy, AA Kolodziejczyk, CA Thaiss… - Nature Reviews …, 2017 - nature.com
Throughout the past century, we have seen the emergence of a large number of
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …

[PDF][PDF] The technology and biology of single-cell RNA sequencing

AA Kolodziejczyk, JK Kim, V Svensson, JC Marioni… - Molecular cell, 2015 - cell.com
The differences between individual cells can have profound functional consequences, in
both unicellular and multicellular organisms. Recently developed single-cell mRNA-…

Diet–microbiota interactions and personalized nutrition

AA Kolodziejczyk, D Zheng, E Elinav - Nature Reviews Microbiology, 2019 - nature.com
Conceptual scientific and medical advances have led to a recent realization that there may
be no single, one-size-fits-all diet and that differential human responses to dietary inputs may …

Accounting for technical noise in single-cell RNA-seq experiments

P Brennecke, S Anders, JK Kim, AA Kołodziejczyk… - Nature …, 2013 - nature.com
Single-cell RNA-seq can yield valuable insights about the variability within a population of
seemingly homogeneous cells. We developed a quantitative statistical method to distinguish …

[HTML][HTML] Classification of low quality cells from single-cell RNA-seq data

T Ilicic, JK Kim, AA Kolodziejczyk, FO Bagger… - Genome biology, 2016 - Springer
Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical
research. One of the key challenges is to ensure that only single, live cells are included in …

[PDF][PDF] Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation

AA Kolodziejczyk, JK Kim, JCH Tsang, T Ilicic… - Cell stem cell, 2015 - cell.com
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-renewal,
and they influence cellular pluripotency state. Here, we report single cell RNA-…

The role of the microbiome in NAFLD and NASH

AA Kolodziejczyk, D Zheng, O Shibolet… - EMBO molecular …, 2019 - embopress.org
Nonalcoholic fatty liver disease ( NAFLD ) is the hepatic manifestation of cardiometabolic
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly becoming …

Aging increases cell-to-cell transcriptional variability upon immune stimulation

…, N Eling, HC Chen, CA Vallejos, AA Kolodziejczyk… - Science, 2017 - science.org
Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects transcriptional …

[HTML][HTML] Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression

JK Kim, AA Kolodziejczyk, T Ilicic… - Nature …, 2015 - nature.com
Single-cell RNA-sequencing (scRNA-seq) facilitates identification of new cell types and gene
regulatory networks as well as dissection of the kinetics of gene expression and patterns of …

[PDF][PDF] The spatiotemporal program of zonal liver regeneration following acute injury

…, S Dan, D Papinutti, A Lifshitz, AA Kolodziejczyk… - Cell Stem Cell, 2022 - cell.com
The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell
approaches are necessary to study this process, given the spatial heterogeneity of liver …