Dysbiosis and the immune system
Throughout the past century, we have seen the emergence of a large number of
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …
[PDF][PDF] The technology and biology of single-cell RNA sequencing
The differences between individual cells can have profound functional consequences, in
both unicellular and multicellular organisms. Recently developed single-cell mRNA-…
both unicellular and multicellular organisms. Recently developed single-cell mRNA-…
Diet–microbiota interactions and personalized nutrition
Conceptual scientific and medical advances have led to a recent realization that there may
be no single, one-size-fits-all diet and that differential human responses to dietary inputs may …
be no single, one-size-fits-all diet and that differential human responses to dietary inputs may …
Accounting for technical noise in single-cell RNA-seq experiments
Single-cell RNA-seq can yield valuable insights about the variability within a population of
seemingly homogeneous cells. We developed a quantitative statistical method to distinguish …
seemingly homogeneous cells. We developed a quantitative statistical method to distinguish …
[HTML][HTML] Classification of low quality cells from single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical
research. One of the key challenges is to ensure that only single, live cells are included in …
research. One of the key challenges is to ensure that only single, live cells are included in …
[PDF][PDF] Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
AA Kolodziejczyk, JK Kim, JCH Tsang, T Ilicic… - Cell stem cell, 2015 - cell.com
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-renewal,
and they influence cellular pluripotency state. Here, we report single cell RNA-…
and they influence cellular pluripotency state. Here, we report single cell RNA-…
The role of the microbiome in NAFLD and NASH
AA Kolodziejczyk, D Zheng, O Shibolet… - EMBO molecular …, 2019 - embopress.org
Nonalcoholic fatty liver disease ( NAFLD ) is the hepatic manifestation of cardiometabolic
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly becoming …
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly becoming …
Aging increases cell-to-cell transcriptional variability upon immune stimulation
Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects transcriptional …
molecular basis of this decline remains unclear. We explored how aging affects transcriptional …
[HTML][HTML] Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression
JK Kim, AA Kolodziejczyk, T Ilicic… - Nature …, 2015 - nature.com
Single-cell RNA-sequencing (scRNA-seq) facilitates identification of new cell types and gene
regulatory networks as well as dissection of the kinetics of gene expression and patterns of …
regulatory networks as well as dissection of the kinetics of gene expression and patterns of …
[PDF][PDF] The spatiotemporal program of zonal liver regeneration following acute injury
…, S Dan, D Papinutti, A Lifshitz, AA Kolodziejczyk… - Cell Stem Cell, 2022 - cell.com
The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell
approaches are necessary to study this process, given the spatial heterogeneity of liver …
approaches are necessary to study this process, given the spatial heterogeneity of liver …