Mitochondria play central roles in energy homeostasis, metabolism, signaling, and apoptosis.
Accordingly, the abundance, morphology, and functional properties of mitochondria are …

PGC-1 was originally identified as a transcriptional coactivator of the nuclear receptor PPARγ.
The expression pattern and induction by exposure to cold have implicated PGC-1 in the …

Estrogen receptor related receptor (ERR)α was one of the first identified (1988) orphan
nuclear receptors. Many of the orphan receptors identified after ERRα were deorphanized in a …

The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1) can induce
mitochondria biogenesis and has been implicated in the development of oxidative type I …

Mitochondrial impairment is hypothesized to contribute to the pathogenesis of insulin resistance.
Mitofusin (Mfn) proteins regulate the biogenesis and maintenance of the mitochondrial …

Estrogen-related receptor α (ERRα) is one of the first orphan nuclear receptors to be identified,
yet its physiological functions are still unclear. We show here that ERRα is an effector of …

The estrogen-related receptor α (ERRα) is one of the first orphan nuclear receptors identified.
Still, we know little about the mechanisms that regulate its expression and its activity. In this …

Mechanisms and signals that regulate transcriptional coactivators are still largely unknown.
Here we provide genetic evidence for a repressor that interacts with and regulates the …

Brain metastases are among the most feared complications in breast cancer, as no therapy
exists that prevents or eliminates breast cancer spreading to the brain. New therapeutic …

Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a tissue-specific and
inducible transcriptional coactivator for several nuclear receptors, plays a key role in energy …