User profiles for A. Kreutzberger
Alex KreutzbergerHarvard Medical School Verified email at tklab.hms.harvard.edu Cited by 1647 |
The role of cholesterol in membrane fusion
ST Yang, AJB Kreutzberger, J Lee, V Kiessling… - Chemistry and physics …, 2016 - Elsevier
Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of lipid …
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of lipid …
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
…, PW Rothlauf, AJB Kreutzberger… - Proceedings of the …, 2020 - National Acad Sciences
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-…
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-…
SARS-CoV-2 requires acidic pH to infect cells
AJB Kreutzberger, A Sanyal… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane
attachment and ends with spike (S) protein–catalyzed membrane fusion depending on …
attachment and ends with spike (S) protein–catalyzed membrane fusion depending on …
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of vaccination-…
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of vaccination-…
Unraveling the mechanisms of calcium-dependent secretion
A Anantharam, AJB Kreutzberger - Journal of General Physiology, 2019 - rupress.org
Ca 2+ -dependent secretion is a process by which important signaling molecules that are
produced within a cell—including proteins and neurotransmitters—are expelled to the …
produced within a cell—including proteins and neurotransmitters—are expelled to the …
[HTML][HTML] Planar supported membranes with mobile SNARE proteins and quantitative fluorescence microscopy assays to study synaptic vesicle fusion
Synaptic vesicle membrane fusion, the process by which neurotransmitter gets released at
the presynaptic membrane is mediated by a complex interplay between proteins and lipids. …
the presynaptic membrane is mediated by a complex interplay between proteins and lipids. …
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge
currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies …
currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies …
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …
pathophysiological processes via its ability to support release of ATP and other cellular …
HIV virions sense plasma membrane heterogeneity for cell entry
ST Yang, AJB Kreutzberger, V Kiessling… - Science …, 2017 - science.org
It has been proposed that cholesterol in host cell membranes plays a pivotal role for cell
entry of HIV. However, it remains largely unknown why virions prefer cholesterol-rich …
entry of HIV. However, it remains largely unknown why virions prefer cholesterol-rich …
Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion
INTRODUCTION Cell membranes are both a protective permeability barrier and a site where
chemical reactions must be catalyzed to sustain life itself. How evolution adapted enzymes …
chemical reactions must be catalyzed to sustain life itself. How evolution adapted enzymes …