Examining the utility of patient-derived xenograft mouse models
Patient-derived xenograft (PDX) models are now being widely used in cancer research and
have the potential to greatly inform our understanding of cancer biology. However, many …
have the potential to greatly inform our understanding of cancer biology. However, many …
Secure vehicular communication systems: implementation, performance, and research challenges
…, G Calandriello, A Held, A Kung… - IEEE …, 2008 - ieeexplore.ieee.org
Vehicular communication systems are on the verge of practical deployment. Nonetheless,
their security and privacy protection is one of the problems that have been addressed only …
their security and privacy protection is one of the problems that have been addressed only …
[PDF][PDF] An expanded universe of cancer targets
The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
Selective inhibition of BET bromodomains
Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts
have been limited to chromatin modifying enzymes, or so-called epigenetic ‘writers’ and ‘…
have been limited to chromatin modifying enzymes, or so-called epigenetic ‘writers’ and ‘…
Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection
…, HW Lee, AV Villarino, DM Livingston, AL Kung… - Science, 2001 - science.org
How cytokines control differentiation of helper T (T H ) cells is controversial. We show that T-bet,
without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies T H 1 effector …
without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies T H 1 effector …
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
C Kanellopoulou, SA Muljo, AL Kung… - Genes & …, 2005 - genesdev.cshlp.org
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species
responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-…
responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-…
[PDF][PDF] MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
…, L Bullinger, RM Pollock, VM Richon, AL Kung… - Cancer cell, 2011 - cell.com
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …
[PDF][PDF] Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
…, DT Frederick, AD Hurley, A Nellore, AL Kung… - Cancer cell, 2013 - cell.com
Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition
of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that …
of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that …
[PDF][PDF] Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically
aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) …
aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) …
SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
The effective use of targeted therapy is highly dependent on the identification of responder
patient populations. Loss of FBW7, which encodes a tumour-suppressor protein, is frequently …
patient populations. Loss of FBW7, which encodes a tumour-suppressor protein, is frequently …