Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription.
In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when …

Dose-dependent effects of haloperidol (2.66 nmol/kg to 79.8 mmol/kg, IP) on levels of
dopamine, homovanillic and (HVA) and dihydroxyphenylacetic acid (DOPAC) were assessed in …

… Fellowship in Biological Psychiatry, funded by Pfizer US Pharmaceuticals, awarded to Amelia
Gallitano. Dr. Gallitano was not an employee or consultant of Pfizer, and the science was …

Recently, genome‐wide association studies (GWAS), meta‐analyses, and replication studies
focusing on bipolar disorder (BD) have implicated the α‐1C subunit of the L‐type voltage‐…

The dentate gyrus (DG) is a hippocampal region that has long been characterized as a critical
mediator of enduring memory formation and retrieval. As such, there is a wealth of studies …

… However, unpublished data from our laboratory indicate significant behavioral abnormalities
in mice lacking only Nab2 (Gallitano, unpublished observation). Despite the paucity of …

Bipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence,
involving complex interactions between numerous genes and environmental factors. Immediate …

The immediate-early gene early growth response 3 (Egr3) is associated with schizophrenia
and expressed at reduced levels in postmortem patients' brains. We have previously …

Serotonin 2A receptors (5-HT 2A Rs) mediate the hallucinogenic effects of psychedelic drugs
and are a key target of the leading class of medications used to treat psychotic disorders. …

… Gallitano-Mendel and colleagues noted that EGR3 is activated downstream of numerous
proteins associated with risk for psychotic illness, including neuregulin 1 (NRG1), calcineurin (…