Protein NMR chemical shifts are highly sensitive to local structure. A robust protocol is
described that exploits this relation for de novo protein structure generation, using as input …

Proteins fold into unique native structures stabilized by thousands of weak interactions that
collectively overcome the entropic cost of folding. Although these forces are “encoded” in the …

The eight mammalian Cbx proteins are chromodomain-containing proteins involved in
regulation of heterochromatin, gene expression, and developmental programs. They are …

Histone modifications and DNA methylation represent two layers of heritable epigenetic
information that regulate eukaryotic chromatin structure and gene activity. UHRF1 is a unique …

The behaviour of the total momentum of a system immersed in the Berendsen thermostat is
analyzed. It has been found that under certain conditions the kinetic energy of the system can …

UHRF1 is a multidomain protein crucially linking histone H3 modification states and DNA
methylation. While the interaction properties of its specific domains are well characterized, little …

Interleaved dimers and higher order symmetric oligomers are ubiquitous in biology but
present a challenge to de novo structure prediction methodology: The structure adopted by a …

NleG homologues constitute the largest family of type 3 effectors delivered by pathogenic E.
coli, with fourteen members in the enterohaemorrhagic (EHEC) O157:H7 strain alone. …

The crucial role of Myc as an oncoprotein and as a key regulator of cell growth makes it
essential to understand the molecular basis of Myc function. The N-terminal region of c-Myc …

Pirh2 (p53-induced RING-H2 domain protein; also known as Rchy1) is an E3 ubiquitin ligase
involved in a negative-feedback loop with p53. Using NMR spectroscopy, we show that …