Shear stress induces noncanonical autophagy in intestinal epithelial monolayers

…, J Ehrman, MR Ahn, J Kondo, AAM Lopez… - Molecular biology of …, 2017 - Am Soc Cell Biol
Flow of fluids through the gut, such as milk from a neonatal diet, generates a shear stress on
the unilaminar epithelium lining the lumen. We report that exposure to physiological levels …

Mutations in the insulator protein Suppressor of Hairy wing induce genome instability

SJ Hsu, EC Stow, JR Simmons, HA Wallace, AM Lopez… - Chromosoma, 2020 - Springer
Insulator proteins orchestrate the three-dimensional organization of the genome. Insulators
function by facilitating communications between regulatory sequences and gene promoters, …

[HTML][HTML] Biodistribution and efficacy of human adipose-derived mesenchymal stem cells following intranodal administration in experimental colitis

M Lopez-Santalla, P Mancheño-Corvo… - Frontiers in …, 2017 - frontiersin.org
Mesenchymal stem cells (MSCs) have a large potential in cell therapy for treatment of
inflammatory and autoimmune diseases, thanks to their immunomodulatory properties. The …

[PDF][PDF] LXR stimulates a metabolic switch and reveals cholesterol homeostasis as a statin target in Tasmanian devil facial tumor disease

MP Ikonomopoulou, Y Lopez-Mancheno, MG Novelle… - Cell Reports, 2021 - cell.com
Devil facial tumor disease (DFTD) and its lack of available therapies are propelling the
Tasmanian devil population toward extinction. This study demonstrates that cholesterol …

Shear stress induces non-canonical autophagic flux in intestinal epithelial

SW Kim, J Ehrman, MR Ahn, J Kondo, AAM Lopez… - Nature, 2013 - Am Soc Cell Biol
Flow of fluids through the gut, such as milk from a neonatal diet, generates a shear stress on
the unilaminar epithelium lining the lumen. We report that exposure to physiological levels …

[HTML][HTML] Comparative analysis between the in vivo biodistribution and therapeutic efficacy of adipose-derived mesenchymal stromal cells administered …

M Lopez-Santalla, P Mancheño-Corvo… - International Journal of …, 2018 - mdpi.com
Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory
diseases. The immunomodulatory effect of MSCs takes place both by direct cell-to-cell contact …

[HTML][HTML] Calcifediol treatment and hospital mortality due to COVID-19: a cohort study

…, J Garcia-Alegria, A Lozano Rodríguez-Mancheño… - Nutrients, 2021 - mdpi.com
Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients.
Objective: To compare the administration or not of oral calcifediol on mortality risk of patients …

Youngest agamid lizards from Western Europe (Sierra de Quibas, Spain, late Early Pleistocene)

…, JM López-García, G Romero, MA Mancheño - Acta Palaeontologica …, 2013 - BioOne
Here we report a new Early Pleistocene record of agamid lizards (Agamidae indet.) from the
Spanish locality of Quibas (ca. 1.3–1.0 Ma), which represents the latest evidence of the …

Convalescent plasma for COVID-19: a multicenter, randomized clinical trial

…, I Romera, J Lora-Tamayo, M Mancheno-Losa… - MedRxiv, 2020 - medrxiv.org
Background Passive immunotherapy with convalescent plasma (CP) is a potential treatment
for COVID-19 for which evidence from controlled clinical trials is lacking. Methods We …

[PDF][PDF] Beta‐2‐Glycoprotein‐I Deficiency Could Precipitate an Antiphospholipid Syndrome‐like Prothrombotic Situation in Patients With Coronavirus Disease 2019

…, M Mancheño‐Losa, Á Marchán‐López… - ACR Open …, 2021 - Wiley Online Library
Objective Patients with coronavirus disease 2019 (COVID‐19) present coagulation
abnormalities and thromboembolic events that resemble antiphospholipid syndrome (APS). This …