High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Background: It is unknown if COVID-19 will exhibit seasonal pattern as other diseases eg,
seasonal influenza. Similarly, some environmental factors (eg, temperature, humidity) have …

Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of complex …

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …

Background Given the effect of chronic diseases on risk of severe COVID-19 infection, the
present pandemic may have a particularly profound impact on socially disadvantaged counties…

Mitochondria (MT), the major site of cellular energy production, are under dual genetic control
by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …