Background & Aims Over the last decade, clinical experiences and research studies raised
concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for …

The iPlant Collaborative (iPlant) is a United States National Science Foundation (NSF)
funded project that aims to create an innovative, comprehensive, and foundational …

Glaucoma filtration surgery (GFS) has been shown to be more eVective at preventing disease
progression than other primary treatment modalities in open angle glaucoma. 1 2 If it were …

Background High rates of sustained virologic response were observed among patients with
hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide …

Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America 1 . Although the recommended treatment for …

Background In phase 2 trials, telaprevir, a hepatitis C virus (HCV) genotype 1 protease
inhibitor, in combination with peginterferon–ribavirin, as compared with peginterferon–ribavirin …

Background As the population that is infected with the hepatitis C virus (HCV) ages, the
number of patients with decompensated cirrhosis is expected to increase. Methods We …

GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled
receptors that are tandemly encoded at a single chromosomal locus in both humans and …

Background In phase 2 studies, treatment with the all-oral combination of the nucleotide
polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of …

Background Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients
who have not had a sustained virologic response to prior interferon-based therapy represents …